How much VRAM does ERNIE 4.5 21B-A3B Instruct need?
ERNIE 4.5 21B-A3B Instruct needs about 13.2 GB of VRAM at Q4_K_M, or 22.6 GB at Q8_0 and 41.8 GB at FP16. That fits a consumer card: the smallest in our set that holds it at Q4_K_M is the RTX 4060 Ti 16GB (16 GB). Weights plus runtime overhead. Budget separately for KV cache, which at 128K is a material share.
Weights-plus-runtime footprint across the six most common quantizations. KV cache is context-dependent and comes on top. A full 128K window is a real share of the budget; size it precisely in the GPU Memory Calculator.
This is a mixture-of-experts model: all 21B parameters must sit in memory, but only about 3B are active per token — so it loads like a 21B model and runs closer to a 3B one.
Can your GPU run ERNIE 4.5 21B-A3B Instruct?
Pick your card — the answer below is computed by the same engine that produces every figure on this page.
RTX 4060 Ti 16GB runs ERNIE 4.5 21B-A3B Instruct at Q4_K_M with 2.0 GB to spare; room left for context and everyday runtime pressure; as a mixture-of-experts model all 21B parameters must be resident even though only 3B are active per token.
Weights plus runtime overhead. KV cache is not included — it depends on context length and this model’s published architecture.
| Weights (Q4_K_M) | 11.9 GB |
| Runtime overhead | 1.3 GB |
| Estimated total | 13.2 GB |
| Usable VRAM (95% of 16 GB) | 15.2 GB |
Across every GPU we track
- RTX 3060 12GBNot enough-1.8 GB
- RTX 4060 Ti 16GBRecommended+2.0 GB
- RTX 4070 Ti SUPERRecommended+2.0 GB
- RTX 3090Excellent+9.6 GB
- RTX 4090Excellent+9.6 GB
- RTX 5090Excellent+17.2 GB
- A100 40GBExcellent+24.8 GB
- RTX A6000Excellent+32.4 GB
- L40SExcellent+32.4 GB
- A100 80GBExcellent+62.8 GB
- H100 80GBExcellent+62.8 GB
- H200 141GBExcellent+120.8 GB
Estimates, not guarantees: real usage moves with runtime, driver, batch size and context. Size a specific context window in the GPU Memory Calculator.
How was this number calculated? Every figure here comes from Bitpute’s documented calculation methodology — parameters, precision, quantization, runtime overhead and usable VRAM, each formula written out in full.
Memory by quantization
| Quant | Weights | + runtime overhead |
|---|---|---|
| FP16 | 39.1 GB | 41.8 GB |
| Q8_0 | 20.8 GB | 22.6 GB |
| Q6_K | 16.0 GB | 17.6 GB |
| Q5_K_M | 13.9 GB | 15.4 GB |
| Q4_K_M | 11.9 GB | 13.2 GB |
| Q4_0 | 11.0 GB | 12.3 GB |
Overhead = 0.75 GB + 5% of weights (CUDA context, buffers). Add KV cache on top. A full 128K window is a real share of the budget.
Which quantization should you actually run?
ERNIE 4.5 21B-A3B Instruct is too large for a 12–16 GB card. On RTX 4070 Ti SUPER, Q4_K_M (13.2 GB) fits though context headroom gets tight — the realistic single-GPU entry point. Higher quality (Q6_K 17.6 GB, FP16 41.8 GB) needs RTX 4090 or multiple GPUs — for occasional use, renting is usually cheaper than buying. As a mixture-of-experts model it must hold all 21B in VRAM but activates only about 3B per token, so it runs much faster than its footprint suggests — memory is the limit here, not speed.
Single-GPU fit at Q4_K_M (13.2 GB + KV)
RTX 3060 12GBRTX 4060 Ti 16GBRTX 4070 Ti SUPERRTX 3090RTX 4090RTX 5090A100 40GBRTX A6000L40SA100 80GBH100 80GBH200 141GB
Where the memory goes
Weights and overhead are exact for Q4_K_M. The KV bar assumes a generic 32-layer transformer at 8K context — your model’s layer count and attention scheme move it, which is what the calculator is for.
Weighing the cheapest card that fits against the next one up? RTX 4060 Ti 16GB vs RTX 3090 compares them on bandwidth, power and which models each one holds.
Common questions
How much VRAM does ERNIE 4.5 21B-A3B Instruct need?
ERNIE 4.5 21B-A3B Instruct needs about 13.2 GB of VRAM at Q4_K_M, 22.6 GB at Q8_0, or 41.8 GB at FP16. That is weights plus about 0.75 GB of runtime overhead and 5% of weight size; KV cache is additional and depends on context length.
What GPU can run ERNIE 4.5 21B-A3B Instruct?
At Q4_K_M the smallest card in our set that fits is the RTX 4060 Ti 16GB (16 GB usable at 95%). At FP16 you need the RTX A6000 (48 GB) or larger.
Can ERNIE 4.5 21B-A3B Instruct run on 24 GB?
Yes. At Q4_K_M it needs about 13.2 GB, which fits inside the ~22.8 GB usable on a 24 GB card.